Cerene Biomedics is in early stages of product development.  Below are selected peer-reviewed references to support the safety and efficacy of cooling.


1 Yang XF, Kennedy BR, Lomber SG, Schmidt RE, Rothman SM. Cooling produces minimal neuropathology in neocortex and hippocampus. Neurobiology of Disease. 2006 Sep;23(3):637-643.
2 Schmitt FC, Buchheim K, Meierkord H, Holtkamp M. Anticonvulsant properties of hypothermia in experimental status epilepticus. Neurobiology of Disease. 2006 Sep;23(3): 689-696.
3 Rothman SM, Smyth MD, Yang XF, Peterson GP. Focal cooling for epilepsy: An alternative therapy that might actually work. Epilepsy & Behavior 2005 Sep;7(2):214-221.
4 Bakken HE, Kawasaki H, Oya H, Greenlee JD, Howard MA 3rd. A device for cooling localized regions of human cerebral cortex. J Neurosurg. 2003 Sep;99(3):604-608.
5 Karkar KM, Garcia PA, Bateman LM, Smyth MD, Barbaro NM, Berger M. Focal cooling suppresses spontaneous epileptiform activity without changing the cortical motor threshold. Epilepsia. 2002 Aug;43(8):932-935.
6 Lomber SG, Payne BR,  Horel JA. The cryoloop: an adaptable reversible cooling deactivation method for behavioral or electrophysiological assessment of neural function. Journal of Neuroscience Methods. 1999 Jan;86(2): 179-194.
7 Sartorius CJ, Berger MS. Rapid termination of intraoperative stimulation-evoked seizures with application of cold Ringer’s lactate to the cortex. J Neurosurg. 1998 Feb;88(2):349-351.